Antihypertensive Drugs

Hypertension is one of the most serious concerns of modern medical practice. It is estimated that in the United States, as many as 60 million people are hypertensive or are being treated with antihypertensive drugs. Among the growing population of elderly Americans, some 15 million have high blood pressure. The level of blood pressure in itself is not a chief concern, since individuals with high blood pressure may be asymptomatic for many years. What is of prime significance is that hypertension has been shown convincingly to be the single most important contributing factor to cardiovascular disease, the leading cause of morbidity and untimely death in the United States. The actual level of pressure that can be considered hypertensive is difficult to define; it depends on a number of factors, including the patient’s age, sex, race, and lifestyle. As a working definition, many cardiovascular treatment centers consider that a diastolic pressure of 90 mm Hg or higher or a systolic pressure of 140 mm Hg or higher represents hypertension. In this chapter, reference is made to the stages of hypertension according to the recommendations of the Sixth Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension is considered to be stage I, or mild, if diastolic pressure is 90 to 99 mm Hg and/or systolic pressure is 140 to 159 mm Hg. Stage II, or moderate, hypertension is diastolic pressure of l00 to 109 mm Hg and/or systolic pressure of 160 to 179 mm Hg. Stage III, or severe, hypertension exists when diastolic pressure is 110 mm Hg or greater and/or systolic pressure is 180 mm Hg or greater. These values should not be considered as absolutes but rather as indicators for facilitating discussion, particularly in relation to the indications for use of specific drugs. Since in general terms hypertension can be defined as the level of blood pressure at which there is risk, the ultimate judgment concerning the severity of hypertension in any given individual must also include a consideration of factors other than diastolic or systolic pressure. D R U G L I S T Antihypertensive Drugs